In our scientific analysis, we measured the quantities of expressed genes that are responsible for pigment production. Grey/white hair with active melanin synthesis showed a similar result as pigmented hair contrary to previous expectations. Meanwhile, the quantity of expressed melanophilin*³ that is in charge of delivering the pigment into the hair matrix*⁴ was reduced. This delivery malfunction results in the appearance of grey/white hair. In conclusion, hair in its early stage of greying may still produce pigment; however, the melanin delivery system needs to be reactivated in order to restore the appearance of pigmented hair.

Three Botanical Extracts that Reactivate Melanophilin
Milbon identified three botanical extracts that are effective in promoting the activity of melanophin: pueraria lobata root extract, thymus serpyllum extract, and chamomilla recutita flower extract. We confirmed that the daily use of a leave-in scalp treatment containing specific amounts of these ingredients can decrease the appearance of grey hair.